Olivia T. Laniak

Apr 26, 2024 | acrjournals.onlinelibrary.wiley.com | Olivia T. Laniak |Norton College |Thomas Winans |Akshay Patel

Oxidative stress is a necessary byproduct of the functioning of the innate and adaptive immune systems.1 Reactive oxygen species (ROS) allow neutrophils to neutralize invading pathogens.2 ROS generation then results in oxidative stress, the absence of which can cause severe immunodeficiency, such as chronic granulomatous disease (CGD).3 However, ROS overproduction may overwhelm degradation pathways and thus contribute to the development of rheumatic diseases.1 Of note, increased mitochondrial...