Akshay Patel

Apr 26, 2024 | acrjournals.onlinelibrary.wiley.com | Olivia T. Laniak |Norton College |Thomas Winans |Akshay Patel

Oxidative stress is a necessary byproduct of the functioning of the innate and adaptive immune systems.1 Reactive oxygen species (ROS) allow neutrophils to neutralize invading pathogens.2 ROS generation then results in oxidative stress, the absence of which can cause severe immunodeficiency, such as chronic granulomatous disease (CGD).3 However, ROS overproduction may overwhelm degradation pathways and thus contribute to the development of rheumatic diseases.1 Of note, increased mitochondrial...

Mar 22, 2024 | nature.com | Nick Huang |Akshay Patel |Frank Middleton |Brandon Wyman |Tamas Faludi |Daniel Krakko

AbstractActivation of the mechanistic target of rapamycin (mTOR) is a key metabolic checkpoint of pro-inflammatory T-cell development that contributes to the pathogenesis of autoimmune diseases, such as systemic lupus erythematosus (SLE), however, the underlying mechanisms remain poorly understood.

Feb 23, 2024 | gamerant.com | Akshay Patel

Destiny 2's Crucible is getting revamped with new game modes and maps, including Artifice Armor rewards for Competitive players. Trials of Osiris will introduce the Passage of Persistence to allow players to continue earning adept weapons even after losses. Matchmaking in Crucible will prioritize lobby balancing to enhance the PvP experience across various game modes. Bungie has revealed its plans to overhaul its PvP modes in Destiny 2.

Jan 31, 2024 | gamerant.com | Akshay Patel

Destiny 2 game director Joe Blackburn is leaving Bungie after completing the playtest for the final expansion, The Final Shape. This departure raises questions about the future of Destiny 2, as Bungie is transitioning to an episodic model and has not announced plans for a sequel. Bungie is working on other projects, such as the revival of Marathon and a new team-based action game, but Blackburn's exit has caused concern in the community.

Jan 30, 2024 | gamerant.com | Akshay Patel

Bungie announced a new collaboration with BioWare to bring Mass Effect-themed cosmetics to Destiny 2, including armor sets, a ship, and more. Unlike previous collaborations, these cosmetics will be available for free to all players, while an emote and finisher can be purchased with Silver. This collaboration could help boost Destiny 2's popularity and earn Bungie praise, especially during a challenging time for the game and the studio.