Olov Andersson

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Inhibition of mammalian mtDNA transcription acts paradoxically to reverse diet-induced hepatosteatosis and obesity - Nature Metabolism

Apr 29, 2024 | nature.com | Florian A. Rosenberger |Arnaud Mourier |Diana Rubalcava-Gracia |Polyxeni Papadea |Olov Andersson |Raffaella Di Lucrezia | +6 more

AbstractThe oxidative phosphorylation system1 in mammalian mitochondria plays a key role in transducing energy from ingested nutrients2. Mitochondrial metabolism is dynamic and can be reprogrammed to support both catabolic and anabolic reactions, depending on physiological demands or disease states. Rewiring of mitochondrial metabolism is intricately linked to metabolic diseases and promotes tumour growth3,4,5.

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