Oluwademilade Nuga

Dec 10, 2024 | biorxiv.org | Matthew V Prifti |Oluwademilade Nuga |Ryan Dulay |Nikhil Patel

AbstractDentatorubral-pallidoluysian atrophy (DRPLA) is a neurodegenerative disorder that presents with ataxia, dementia and epilepsy. As a member of the polyglutamine family of diseases, DRPLA is caused by abnormal CAG triplet expansion beyond 48 repeats in the protein-coding region of ATROPHIN 1 (ATN1), a transcriptional co-repressor. To better understand DRPLA, we generated new Drosophila lines that express full-length, human ATN1 with a normal (Q7) or pathogenic (Q88) repeat.

May 10, 2024 | biorxiv.org | Oluwademilade Nuga |Kristin J. Richardson |Nikhil Patel |Xusheng Wang

AbstractUbiquitin controls many cellular processes via its post-translational conjugation onto substrates. Its use is highly variable due to its ability to form poly-ubiquitin with various topologies. Among them, linear chains have emerged as important regulators of immune responses and protein degradation.