Omar O. Abudayyeh

Dec 15, 2024 | nature.com | Omar O. Abudayyeh

AbstractProgrammable gene integration technologies are an emerging modality with exciting applications in both basic research and therapeutic development. Programmable addition via site-specific targeting elements (PASTE) is a programmable gene integration approach for precise and efficient programmable integration of large DNA sequences into the genome.

Aug 9, 2024 | nature.com | Omar O. Abudayyeh |Jonathan S. Gootenberg

Artificial intelligence-enabled computational tools not only help us to elucidate biological processes but also facilitate the programming of biology through molecular and cellular engineering.

May 12, 2024 | nature.com | Jonathan S. Weissman |Omar O. Abudayyeh

Correction to: Nature Reviews Molecular Cell Biology https://doi.org/10.1038/s41580-023-00697-6, published online 2 February 2024In the version of the article initially published, there were errors in Fig. 1b where the text now reading “Transversion C to G” and “Transition A to G” originally read “Transition C to G” and “Transversions A to G.” The figure has now been amended in the HTML and PDF versions of the article. About this articleVilliger, L., Joung, J., Koblan, L. et al.

Feb 1, 2024 | nature.com | Jonathan S. Weissman |Omar O. Abudayyeh

AbstractOur ability to edit genomes lags behind our capacity to sequence them, but the growing understanding of CRISPR biology and its application to genome, epigenome and transcriptome engineering is narrowing this gap. In this Review, we discuss recent developments of various CRISPR-based systems that can transiently or permanently modify the genome and the transcriptome.