Óscar Yanes

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Metabolic reprogramming by Acly inhibition using SB-204990 alters glucoregulation and modulates molecular mechanisms associated with aging - Communications Biology

Mar 8, 2023 | nature.com | Isabel Espadas |Michael Petr |Óscar Yanes |Maria Vinaixa |Daniel López-López |Jose Reyes | +9 more

AbstractATP-citrate lyase is a central integrator of cellular metabolism in the interface of protein, carbohydrate, and lipid metabolism. The physiological consequences as well as the molecular mechanisms orchestrating the response to long-term pharmacologically induced Acly inhibition are unknown.

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