Otmane Bouchatta

Nov 4, 2024 | nature.com | Huasheng Yu |Saad S. Nagi |Dmitry Usoskin |Yizhou Hu |Otmane Bouchatta |Hanying Yan | +10 more

AbstractThe versatility of somatosensation arises from heterogeneous dorsal root ganglion (DRG) neurons. However, soma transcriptomes of individual human (h)DRG neurons—critical information to decipher their functions—are lacking due to technical difficulties. In this study, we isolated somata from individual hDRG neurons and conducted deep RNA sequencing (RNA-seq) to detect, on average, over 9,000 unique genes per neuron, and we identified 16 neuronal types.