P. Kent Langston

Nov 6, 2023 | science.org | John G. McKendrick |P. Kent Langston |Rosanne Spolski |Alexandra Schafer

AbstractNon-antigen vaccines that broadly activate innate immune responses reduce mortality against hospital-acquired bacterial and fungal pathogens. SIGN UP FOR THE SCIENCEADVISER NEWSLETTER The latest news, commentary, and research, free to your inbox daily Nosocomial or health care–associated infections (HAI) affect ~10% of all in-care patients, causing severe complications, often delaying discharge, and imposing a tremendous financial burden on the health care systems.

Nov 3, 2023 | science.org | John G. McKendrick |P. Kent Langston |Rosanne Spolski |Peng Li

Distinct use of super-enhancer elements controls cell type–specific CD25 transcription and functionRosanne Spolski https://orcid.org/0009-0002-1511-9349, Peng Li https://orcid.org/0000-0002-4721-5936, [...] , Vivek Chandra https://orcid.org/0000-0002-4047-015X, Boyoung Shin https://orcid.org/0000-0001-7926-5527, [...] , Shubham Goel, Keiko Sakamoto, Chengyu Liu https://orcid.org/0000-0002-5136-9225, Jangsuk Oh, Min Ren, [...] , Yutaka Enomoto https://orcid.org/0000-0002-6346-9362, Erin E.

Nov 3, 2023 | sciencemag.org | John G. McKendrick |P. Kent Langston |Rosanne Spolski |Alexandra Schafer

Editors' ChoiceFOCIS HIGHLIGHTSNosocomial or health care–associated infections (HAI) affect ~10% of all in-care patients, causing severe complications, often delaying discharge, and imposing a tremendous financial burden on the health care systems. A wide range of often unrelated pathogens, including Gram-negative and Gram-positive bacteria and fungal pathogens, cause HAI. Yet they share one thing in common: They are antimicrobial resistant (AMR).

Nov 2, 2023 | sciencemag.org | John G. McKendrick |P. Kent Langston |Rosanne Spolski |Peng Li

Published In Science ImmunologyVolume 8 | Issue 89November 2023Article versionsSubmission historyReceived: 24 May 2023Accepted: 10 October 2023PermissionsRequest permissions for this article. AcknowledgmentsWe thank N. Du for help with mast cell STAT5 ChIP-seq studies and K. Zhao for valuable discussions and critical comments. For ChIP-seq and RNA-seq analysis, DNA sequencing was performed in the NHLBI DNA Sequencing Core.