Panpan Hou

Jul 3, 2024 | biorxiv.org | Panpan Hou |Lu Zhao |Ling Zhong |Jingyi Shi

AbstractThe cardiac KCNQ1+KCNE1 (IKs) channel regulates heart rhythm in both normal and stress conditions. Under stress, the β-adrenergic stimulation elevates the intracellular cAMP level, leading to KCNQ1 phosphorylation by protein kinase A and increased IKs, which shortens action potentials to adapt to accelerated heart rate.