Jingyi Shi

Oct 18, 2024 | biorxiv.org | Lu Zhao |Kevin Xu |Irina A. Talyzina |Jingyi Shi

AbstractSonogenetics offers non-invasive and cell-type specific modulation of cells genetically engineered to express ultrasound-sensitive actuators. Finding an ion channel to serve as sonogenetic actuator it critical for advancing this promising technique. Here, we show that ultrasound can activate human TRP channel hTRPV4.

Jul 3, 2024 | biorxiv.org | Panpan Hou |Lu Zhao |Ling Zhong |Jingyi Shi

AbstractThe cardiac KCNQ1+KCNE1 (IKs) channel regulates heart rhythm in both normal and stress conditions. Under stress, the β-adrenergic stimulation elevates the intracellular cAMP level, leading to KCNQ1 phosphorylation by protein kinase A and increased IKs, which shortens action potentials to adapt to accelerated heart rate.

Apr 28, 2024 | mdpi.com | Yifei Liu |Yao Jie Xie |Lei Peng |Jingyi Shi

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