Pantelitsa Dimitriou

1 month ago | biorxiv.org | Pantelitsa Dimitriou |Jason T Sengel |Mark Wallace |Guanzhong Zhai

AbstractA defining feature of living cells is their ability to self-replicate; but creating artificial cells with this capability remains challenging, due to the complexity of biological division machinery. Rather than seeking to reconstitute this machinery, here we take direct control of DNA replication and compartment division using digital microfluidics.

May 31, 2024 | nature.com | Pantelitsa Dimitriou |Jin Billy Li |William Jamieson |Johannes Schneider |Oliver Kieran Castell

AbstractDroplet Interface Bilayers (DIBs) constitute a commonly used model of artificial membranes for synthetic biology research applications. However, their practical use is often limited by their requirement to be surrounded by oil. Here we demonstrate in-situ bilayer manipulation of submillimeter, hydrogel-encapsulated droplet interface bilayers (eDIBs). Monolithic, Cyclic Olefin Copolymer/Nylon 3D-printed microfluidic devices facilitated the eDIB formation through high-order emulsification.

Jun 25, 2023 | biorxiv.org | jin Li |William Jamieson |Johannes Schneider |Pantelitsa Dimitriou

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