Paola Valsasina

1 week ago | onlinelibrary.wiley.com | Monica Margoni |Paola Valsasina |Paolo Preziosa |Martina Rubin

1 Introduction Spinal cord lesions and atrophy, particularly in the cervical region, are common in adult multiple sclerosis (MS) patients and correlate with clinical disability [1-3]. In pediatric MS, spinal cord damage remains largely unexplored, with a few studies reporting neither significant atrophy nor microstructural abnormalities compared to healthy controls (HC) [4, 5].

Nov 18, 2024 | jnnp.bmj.com | Maria A Rocca |Paola Valsasina |Francesco Romano |Nicolò Tedone

AbstractBackground Research on cognitive rehabilitation (CR) and aerobic exercise (EX) to improve cognition in progressive multiple sclerosis (PMS) remains limited. CogEx trial investigated the effectiveness of CR and EX in PMS: here, we present MRI substudy volumetric and task-related functional MRI (fMRI) findings. Methods Participants were randomised to: ‘CR plus EX’, ‘CR plus sham EX (EX-S)’, ‘EX plus sham CR (CR-S)’ and ‘CR-S plus EX-S‘ and attended 12-week intervention.

May 16, 2024 | jnnp.bmj.com | Maria A Rocca |Paola Valsasina |Francesco Romano |Nicolò Tedone

Cognitive rehabilitation effects on grey matter volume and Go-NoGo activity in progressive multiple sclerosis: results from the CogEx trial Statistics from Altmetric.com Request Permissions If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.

Feb 19, 2024 | journals.sagepub.com | Maria A Rocca |Paola Valsasina |Nicolò Tedone |Giulia D’Amore

IntroductionMultiple sclerosis (MS) is characterized by complex pathological substrates, resulting in non-uniform clinical manifestations and variable disease progression.1 Therefore, determining biomarkers associated with an unfavorable disease course is of paramount importance to optimize patients’ management. Magnetic resonance imaging (MRI)–derived measures are good candidates for identifying mechanisms associated with disability progression and cognitive deterioration.