Partha Dutta

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Haplo‐insufficiency of Profilin1 in vascular endothelial cells is beneficial but not sufficient to confer protection against experimentally induced atherosclerosis

Apr 16, 2024 | onlinelibrary.wiley.com | Abigail Allen-Gondringer |David Gau |Partha Dutta |Partha Roy

1 INTRODUCTION Cardiovascular diseases are a leading cause of death world-wide, contributing to approximately 17.9 million deaths a year (Tsao et al., 2023). The most common form, ischemic heart disease, remains the leading cause of cardiovascular-related death, and develops due to formation of atherosclerotic plaques in the blood vessels (Libby et al., 2019).
Haplo-insufficiency of Profilin1 in vascular endothelial cells is beneficial but not sufficient to confer protection against experimentally induced atherosclerosis

Dec 7, 2023 | biorxiv.org | Partha Dutta |Partha Roy |Abigail Allen-Gondringer

AbstractActin cytoskeleton plays an important role in various aspects of atherosclerosis, a key driver of ischemic heart disease. Actin-binding protein Profilin1 (Pfn1) is overexpressed in atherosclerotic plaques in human disease, and Pfn1, when partially depleted globally in all cell types, confers atheroprotection in vivo. This study investigates the impact of endothelial cell (EC)-specific partial loss of Pfn1 expression in atherosclerosis development.

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