David Gau

Jun 28, 2024 | biorxiv.org | Pooja Chawla |David Gau |Fangyuan Chen |Niharika Welling

AbstractBone is a frequent site for breast cancer metastasis. Conditioning of the local tumor microenvironment (TME) through crosstalk between tumor cells and bone resident cells in the metastatic niche is a major driving force for bone colonization of breast cancer cells.

Apr 16, 2024 | onlinelibrary.wiley.com | Abigail Allen-Gondringer |David Gau |Partha Dutta |Partha Roy

1 INTRODUCTION Cardiovascular diseases are a leading cause of death world-wide, contributing to approximately 17.9 million deaths a year (Tsao et al., 2023). The most common form, ischemic heart disease, remains the leading cause of cardiovascular-related death, and develops due to formation of atherosclerotic plaques in the blood vessels (Libby et al., 2019).

Dec 22, 2023 | biorxiv.org | Ian Eder |Virginia Yu |Fangyuan Chen |David Gau

AbstractDysregulated actin cytoskeleton gives rise to aberrant cell motility and metastatic spread of tumor cells. The MRTF-SRF transcriptional complex plays a key role in regulating the expressions of actin cytoskeleton-modulatory genes. In this study, we demonstrate that interaction between MRTF and SRF is critical for migration and invasion of breast cancer cells.

Dec 20, 2023 | jbc.org | David Gau |Morgan M.C. Ricci |Andrew Orenberg |Lee Ohayon

ABSTRACTMembrane poly-phosphoinositides (PPIs) are lipid-signaling molecules that undergo metabolic turnover and influence a diverse range of cellular functions. PPIs regulate the activity and/or spatial localization of a number of actin-binding proteins (ABPs) through direct interactions; however, it is much less clear whether ABPs could also be an integral part in regulating PPI signaling.

Dec 8, 2023 | biorxiv.org | Pooja Chawla |David Gau |Fangyuan Chen |Niharika Welling

AbstractBone is a frequent site for breast cancer metastasis. Conditioning of local tumor microenvironment through crosstalk between tumor cells and bone resident cells in the metastatic niche is a major driving force for bone colonization of cancer cells.