Pascal Espig

Jun 5, 2023 | jamanetwork.com | Philipp M. Lepper |Sebastian Mang |Torben M. Rixecker |Pascal Espig

Daratumumab for a Patient With Refractory Antineutrophil Cytoplasmatic Antibody–Associated Vasculitis Antineutrophil cytoplasmatic antibody (ANCA)–associated vasculitis (AAV) is characterized by multisystem organ involvement with necrotizing granulomatous inflammation and vasculitis.1 ANCA antibodies are considered both specific and pathogenic for this group of autoimmune diseases.2 Hence, B-cell depletion by anti-CD20 therapy has shown substantial benefit and is now considered the standard...