Patrick Deelen

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PICALO: principal interaction component analysis for the identification of discrete technical, cell-type, and environmental factors that mediate eQTLs | Genome Biology | Full Text

Jan 22, 2024 | genomebiology.biomedcentral.com | Martijn Vochteloo |Patrick Deelen |Ellen A. Tsai |Heiko Runz |Sergio Andreu-Sánchez |Jingyuan Fu | +4 more

PICALO is an EM-based algorithm for the identification of known and unknown contexts that influence the regulatory effect of genetic variants on gene expression. PICALO takes as input a set of eQTLs and their corresponding expression and genotype data, as well as a set of starting positions (e.g., potential context components). Optional arguments allow for the correction of technical covariates both with and without an interaction term.

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