Heiko Runz

Feb 25, 2024 | nature.com | Max Lam |Jimmy Liu |Daniel F Levey |Joel Gelernter |Murray B. Stein |Ellen A. Tsai | +3 more

AbstractNearly two hundred common-variant depression risk loci have been identified by genome-wide association studies (GWAS). However, the impact of rare coding variants on depression remains poorly understood. Here, we present whole-exome sequencing analyses of depression with seven different definitions based on survey, questionnaire, and electronic health records in 320,356 UK Biobank participants.

Jan 22, 2024 | genomebiology.biomedcentral.com | Martijn Vochteloo |Patrick Deelen |Ellen A. Tsai |Heiko Runz |Sergio Andreu-Sánchez |Jingyuan Fu | +4 more

PICALO is an EM-based algorithm for the identification of known and unknown contexts that influence the regulatory effect of genetic variants on gene expression. PICALO takes as input a set of eQTLs and their corresponding expression and genotype data, as well as a set of starting positions (e.g., potential context components). Optional arguments allow for the correction of technical covariates both with and without an interaction term.