Patrick Hanna

Nov 3, 2024 | biorxiv.org | Maike Thamsen Dunyak |Patrick Hanna |Angela X Nan |Jessica Von Stetina

AbstractIntegrase-mediated Programmable Genomic Integration (I-PGI) uses a Cas9 nickase (nCas9) with a reverse transcriptase (RT), to write a large serine integrase (LSI) target site (attB/P, here called beacon) in a programmed location. Co-delivery of the LSI and a DNA template containing the cognate recognition site results in precise integration of the template in a specific genomic location.

Oct 13, 2024 | biorxiv.org | Jenny Xie |Maike Thamsen Dunyak |Patrick Hanna |Angela X Nan

New Results Curative levels of endogenous gene replacement achieved in non-human primate liver using programmable genomic integration Jenny Xie, Maike Thamsen Dunyak, Patrick Hanna, Angela X Nan, Brett Estes, Jesse C Cochrane, Shuai Wu, Jie Wang, Connor McGinnis, Qiang Wang, Rejina Pokharel, Dev Paudel, Jason Zhang, Dan Li, Parth Amin, Siddharth Narayan, Angela Hsia, Dane Z Hazelbaker, Xiarong Shi, Meredith Packer, Brian Duke, Ryan Dickerson, Charlotte Piard, Martin Meagher, Jason Gatlin,...