Patrick Pearson

Jul 22, 2023 | mdpi.com | Adam Lynch |Patrick Pearson |Sergey N Savinov |Andrew Li

Abstract:Borrelia burgdorferi, the causative agent of Lyme disease, has a highly reduced genome and relies heavily on glycolysis for carbon metabolism. As such, established inhibitors of lactate dehydrogenase (LDH) were evaluated in cultures to determine the extent of their impacts on B. burgdorferi growth. Both racemic and enantiopure (AT-101) gossypol, as well as oxamate, galloflavin, and stiripentol, caused the dose-dependent suppression of B. burgdorferi growth in vitro.

Jul 12, 2023 | mdpi.com | Allison Snow |Patrick Pearson |Guang Xu |David Allen

This is an early access version, the complete PDF, HTML, and XML versions will be available soon. Open AccessArticlebyAllison A. Snow 1,2,*, Patrick Pearson 3, Guang Xu 3, David N. Allen 4, Roberto Santamaria 5 and Stephen M.