Paula Doria-Borrell

Jan 8, 2025 | cell.com | Georgia Lea |Paula Doria-Borrell |Ana Ferrero-Micó |Anakha Varma |Claire Simon |Holly Anderson | +8 more

IntroductionThe isolation and culture of human embryonic stem cells (hESCs) has been invaluable in building our understanding of pluripotency, cell fate commitment, differentiation, epigenetic programming, and gene regulation in human development.1,2 The derivation of the analogous cells for the human placental lineage has taken longer to develop and hence these processes in trophoblast remain less well understood.

Aug 26, 2024 | nature.com | Vicente Pérez-García |Paula Doria-Borrell

AbstractThe placenta, a pivotal organ in mammalian reproduction, allows nutrient exchange and hormonal signaling between the mother and the developing fetus. Understanding its molecular intricacies is essential for deciphering normal embryonic development and pathological conditions such as tumorigenesis. Here, we explore the multifaceted role of the tumor suppressor BRCA1-associated protein 1 (BAP1) in cancer and placentation.