Pedro Farinha

Apr 3, 2024 | nature.com | Jie Li |Christopher R Chin |Cem Meydan |Pedro Farinha |Yiyue Jiang |Martin Rivas | +9 more

AbstractDespite regulating overlapping gene enhancers and pathways, CREBBP and KMT2D mutations recurrently co-occur in germinal center (GC) B cell-derived lymphomas, suggesting potential oncogenic cooperation. Herein, we report that combined haploinsufficiency of Crebbp and Kmt2d induces a more severe mouse lymphoma phenotype (vs either allele alone) and unexpectedly confers an immune evasive microenvironment manifesting as CD8+ T-cell exhaustion and reduced infiltration.