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Jan 15, 2025 | 
nature.com | Rui Yang |Renhe Luo |Martin Rivas |Martín A. Rivas |Darko Barisic |Alireza Karbalayghareh | +11 more
Correction to: Nature Communications https://doi.org/10.1038/s41467-024-53628-0, published online 01 November 2024In this article the affiliation ‘Department of Biochemistry & Molecular Biology; Sylvester Comprehensive Cancer Center, University of Miami Miller School of Medicine, Miami, FL, USA’ for Martin A. Rivas was missing. The original article has been corrected.
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Nov 21, 2024 | 
kentucky.com | Christopher R Chin
I remember when I realized I was Asian. It was a comment on the school playground-that I was hanging out with a "white boy." Before, there was no difference between us. My friend and I just had fun together. But after that comment, I looked in the mirror and realized I was different. Growing up in Bayside, New York-I was surrounded by Asian people. I thought all of America was like this-that we were the ethnic majority.
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Nov 21, 2024 | 
newsweek.com | Christopher R Chin
CLOSE X By Christopher Chin Share✓ Link copied to clipboard! I remember when I realized I was Asian. It was a comment on the school playground—that I was hanging out with a "white boy." Before, there was no difference between us. My friend and I just had fun together. But after that comment, I looked in the mirror and realized I was different. Growing up in Bayside, New York—I was surrounded by Asian people. I thought all of America was like this—that we were the ethnic majority.
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Nov 1, 2024 | 
nature.com | Rui Yang |Renhe Luo |Martin Rivas |Martín A. Rivas |Darko Barisic |Alireza Karbalayghareh | +11 more
AbstractIdentifying cell-type-specific 3D chromatin interactions between regulatory elements can help decipher gene regulation and interpret disease-associated non-coding variants. However, achieving this resolution with current 3D genomics technologies is often infeasible given limited input cell numbers. We therefore present ChromaFold, a deep learning model that predicts 3D contact maps, including regulatory interactions, from single-cell ATAC sequencing (scATAC-seq) data alone.
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Jun 11, 2024 | 
nature.com | Eliah G. Overbey |JangKeun Kim |Braden T. Tierney |Jiwoon Park |Deena Najjar |Remi Klotz | +30 more
AbstractSpaceflight induces molecular, cellular, and physiological shifts in astronauts and poses myriad biomedical challenges to the human body, which are becoming increasingly relevant as more humans venture into space1-6. Yet, current frameworks for aerospace medicine are nascent and lag far behind advancements in precision medicine on Earth, underscoring the need for rapid development of space medicine databases, tools, and protocols.
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Jun 11, 2024 | 
nature.com | Christopher Mason |James Green |Jordan Baechle |Mathias Basner |Susan Bailey |Joseph Borg | +34 more
AbstractThe recent acceleration of commercial, private and multi-national spaceflight has created an unprecedented level of activity in low Earth orbit, concomitant with the largest-ever number of crewed missions entering space and preparations for exploration-class (lasting longer than one year) missions. Such rapid advancement into space from many new companies, countries and space-related entities has enabled a ‘second space age’.
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Jun 11, 2024 | 
nature.com | JangKeun Kim |Eliah G. Overbey |Richa Batra |Annalise Schweickart |Deena Najjar |Cem Meydan | +6 more
AbstractAs spaceflight becomes more common with commercial crews, blood-based measures of crew health can guide both astronaut biomedicine and countermeasures. By profiling plasma proteins, metabolites, and extracellular vesicles/particles (EVPs) from the SpaceX Inspiration4 crew, we generated “spaceflight secretome profiles,” which showed significant differences in coagulation, oxidative stress, and brain-enriched proteins.
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Jun 10, 2024 | 
nature.com | JangKeun Kim |Christopher R Chin |Tammy Liu |Irina Matei |Cem Meydan |Masafumi Muratani | +7 more
AbstractIt is now widely recognised that the environment in space activates a diverse set of genes involved in regulating fundamental cellular pathways. This includes the activation of genes associated with blood homeostasis and erythropoiesis, with a particular emphasis on those involved in globin chain production.
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Jun 10, 2024 | 
nature.com | JangKeun Kim |Braden T. Tierney |Eliah G. Overbey |Ezequiel Dantas |Jiwoon Park |Fei Wu | +16 more
AbstractSpaceflight induces an immune response in astronauts. To better characterize this effect, we generated single-cell, multi-ome, cell-free RNA (cfRNA), biochemical, and hematology data for the SpaceX Inspiration4 (I4) mission crew. We found that 18 cytokines/chemokines related to inflammation, aging, and muscle homeostasis changed after spaceflight.
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May 7, 2024 | 
hotcars.com | Christopher R Chin
Lamborghini CMO Federico Foschini confirms arrival of Huracán's hybrid successor in August this year, during our exclusive video walkaround of the Urus SE. Speculations suggest the hybrid Huracán could feature V-10 or twin-turbo V-8 from Urus SE with Revuelto-inspired design elements. August reveal of the Huracán successor is expected during Monterey Car Week, targeting enthusiasts and buyers at the Pebble Beach Concours d'Elegance.
