Peter C. Ruben

Sep 28, 2024 | nature.com | Frances Thomas |Mohamed Fouda |Vitaliy Mykhaylyk |Martin B. Ulmschneider |Peter C. Ruben

AbstractNeuronal hyperexcitability is a key element of many neurodegenerative disorders including the motor neuron disease Amyotrophic Lateral Sclerosis (ALS), where it occurs associated with elevated late sodium current (INaL). INaL results from incomplete inactivation of voltage-gated sodium channels (VGSCs) after their opening and shapes physiological membrane excitability. However, dysfunctional increases can cause hyperexcitability-associated diseases.