Peter D. Kwong

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Mucosal prime-boost immunization with live murine pneumonia virus-vectored SARS-CoV-2 vaccine is protective in macaques - Nature Communications

Apr 25, 2024 | nature.com | Christine Nelson |Hong-Su Park |Cindy Luongo |Shirin Munir |Peter D. Kwong |Kennichi Dowdell | +3 more

AbstractImmunization via the respiratory route is predicted to increase the effectiveness of a SARS-CoV-2 vaccine. Here, we evaluate the immunogenicity and protective efficacy of one or two doses of a live-attenuated murine pneumonia virus vector expressing SARS-CoV-2 prefusion-stabilized spike protein (MPV/S-2P), delivered intranasally/intratracheally to male rhesus macaques.

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