Peter D. Kwong

1 month ago | cell.com | Jacob Glanville |Mark bellin |Sergei Pletnev |Baoshan Zhang |Joel Christian Andrade |Sangil Kim | +13 more

Keywords antivenom broadly neutralizing antibody elapid monoclonal antibody neurotoxin-protective antibody 3FTX LNX SNX PLA2 Introduction Snake-bite envenoming, which was added to the World Health Organization (WHO) list of neglected tropical diseases in 2017,1 causes 81,000–138,000 deaths and 300,000–400,000 permanent disabilities annually.2,3 For over a century, the standard treatment has been antivenom—a polyclonal serum derived from animals immunized with venom from one or more species of...

Feb 4, 2025 | cell.com | M. Gordon Joyce |Wei Bu |Wei-Hung Chen |Rebecca A. Gillespie |Sarah Andrews |Adam K. Wheatley | +13 more

Keywords Herpesvirus Epstein-Barr virus EBV antibody therapeutics mAb sites of vulnerability gp350 human complement receptor 2 CR2 molecular mimicry Introduction Epstein-Barr virus (EBV), also known as human herpesvirus 4, infects the vast majority (>95%) of the world’s adults and is responsible for >125,000 cases of infectious mononucleosis per year in the United States.1,2 EBV is a γ-herpesvirus that infects multiple cell types including B cells and epithelial cells, establishing a...

Apr 25, 2024 | nature.com | Christine Nelson |Hong-Su Park |Cindy Luongo |Shirin Munir |Peter D. Kwong |Kennichi Dowdell | +3 more

AbstractImmunization via the respiratory route is predicted to increase the effectiveness of a SARS-CoV-2 vaccine. Here, we evaluate the immunogenicity and protective efficacy of one or two doses of a live-attenuated murine pneumonia virus vector expressing SARS-CoV-2 prefusion-stabilized spike protein (MPV/S-2P), delivered intranasally/intratracheally to male rhesus macaques.