Peter E. Lipsky

Nov 6, 2024 | nature.com | Thomas E. Dorner |Peter E. Lipsky

AbstractEmerging evidence indicates that memory B cells are dysfunctional in systemic lupus erythematosus (SLE). They are hyporesponsive to signalling through the B cell receptor (BCR) but retain responsiveness to Toll-like receptor (TLR) and type I interferon signalling, as well as to T cell-mediated activation via CD40–CD154.

Apr 8, 2024 | healio.com | Shenaz Bagha |Peter E. Lipsky

You've successfully added Lupus to your alerts. You will receive an email when new content is published. Click Here to Manage Email Alerts We were unable to process your request. Please try again later. If you continue to have this issue please contact [email protected]. Key takeaways: The blood test aims to predict lupus flares and drug targets rapidly by analyzing RNA gene expression. Recruitment is underway for an open-label, multicenter U.S. trial.

Apr 1, 2023 | nature.com | Peter E. Lipsky

AbstractSystemic lupus erythematosus (SLE) is a multi-organ autoimmune disorder with a prominent genetic component. Individuals of Asian-Ancestry (AsA) disproportionately experience more severe SLE compared to individuals of European-Ancestry (EA), including increased renal involvement and tissue damage. However, the mechanisms underlying elevated severity in the AsA population remain unclear.