Thomas E. Dorner

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Articles

Safety and Efficacy of Ianalumab in Patients With Sjögren's Disease: 52‐Week Results From a Randomized, Placebo‐Controlled, Phase 2b Dose‐Ranging Study

Nov 19, 2024 | acrjournals.onlinelibrary.wiley.com | Thomas E. Dorner |Simon J. Bowman |Robert Fox |Xavier Mariette |Athena Papas |Filipe Barcelos | +7 more
The essential roles of memory B cells in the pathogenesis of systemic lupus erythematosus - Nature Reviews Rheumatology

Nov 6, 2024 | nature.com | Thomas E. Dorner |Peter E. Lipsky

AbstractEmerging evidence indicates that memory B cells are dysfunctional in systemic lupus erythematosus (SLE). They are hyporesponsive to signalling through the B cell receptor (BCR) but retain responsiveness to Toll-like receptor (TLR) and type I interferon signalling, as well as to T cell-mediated activation via CD40–CD154.

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