Peter H. Suzuki

Sep 24, 2024 | biorxiv.org | Raeline Valbuena |Josh Tycko |Peter H. Suzuki |Kaitlyn Spees

AbstractRegulatory proteins have evolved diverse repressor domains (RDs) to enable precise context-specific repression of transcription. However, our understanding of how sequence variation impacts the functional activity of RDs is limited. To address this gap, we generated a high-throughput mutational scanning dataset measuring the repressor activity of 115,000 variant sequences spanning more than 50 RDs in human cells.