Raeline Valbuena

Sep 24, 2024 | biorxiv.org | Raeline Valbuena |Josh Tycko |Peter H. Suzuki |Kaitlyn Spees

AbstractRegulatory proteins have evolved diverse repressor domains (RDs) to enable precise context-specific repression of transcription. However, our understanding of how sequence variation impacts the functional activity of RDs is limited. To address this gap, we generated a high-throughput mutational scanning dataset measuring the repressor activity of 115,000 variant sequences spanning more than 50 RDs in human cells.

Aug 23, 2024 | nature.com | Christine Yeh |Olivia Laveroni |Subin Kim |Aihui Wang |Brooke Liang |Raeline Valbuena | +4 more

AbstractThe drivers of immune evasion are not entirely clear, limiting the success of cancer immunotherapies. Here we applied single-cell spatial and perturbational transcriptomics to delineate immune evasion in high-grade serous tubo-ovarian cancer. To this end, we first mapped the spatial organization of high-grade serous tubo-ovarian cancer by profiling more than 2.5 million cells in situ in 130 tumors from 94 patients.