Peter van Galen

May 8, 2024 | nature.com | Qingyu Luo |Miguel Prado |Xiaowei Wu |Ran Xu |Peter van Galen |John G. Doench | +4 more

AbstractPhosphoinositide-3-kinase-γ (PI3Kγ) is implicated as a target to repolarize tumour-associated macrophages and promote antitumour immune responses in solid cancers1,2,3,4. However, cancer cell-intrinsic roles of PI3Kγ are unclear. Here, by integrating unbiased genome-wide CRISPR interference screening with functional analyses across acute leukaemias, we define a selective dependency on the PI3Kγ complex in a high-risk subset that includes myeloid, lymphoid and dendritic lineages.