Petr Broz

Dec 4, 2024 | nature.com | Petr Broz

NEWS AND VIEWS 04 December 2024 During some types of cell death, cells rupture to release molecules that cause inflammation. This must happen at the right time and place to restore health. How is the protein NINJ1 regulated so that cells break open only when they die? Inflammation, the movement of immune cells to an area of infection or injury, is important for tackling infections and restoring health.

Jun 17, 2024 | nature.com | Petr Broz

Gasdermin D (GSDMD) is the pore-forming executor of pyroptosis and cytokine secretion during inflammasome activation. In a recent study in Nature, Du et al. report that S-palmitoylation of human GSDMD at Cys191 (mouse Cys192) is a key regulatory step that controls both its activation and interaction with membranes.

Jan 3, 2024 | nature.com | Marek Basler |Petr Broz |Knut Drescher |Alexander Harms |Andreas Hierlemann |Sebastian Hiller | +11 more

In vitro models mimicking in-patient conditions have the potential to yield exciting opportunities for antibiotic research and revitalize future antibiotic discovery and development. Antibiotics have revolutionized modern medicine. However, their usefulness in treating bacterial infections and as prophylactics accompanying chemotherapy or surgery is under threat by the rise of antibiotic-resistant bacteria.