Alexander Harms

Dec 11, 2024 | nature.com | Haidai Hu |Philipp F. Popp |Aritz Roa-Eguiara |Nicole R. Rutbeek |Leighton J Payne |Dorentina Humolli | +8 more

AbstractZorya is a recently identified and widely distributed bacterial immune system that protects bacteria from viral (phage) infections. Three Zorya subtypes have been discovered, each containing predicted membrane-embedded ZorAB complexes paired with soluble subunits that differ among Zorya subtypes, notably ZorC and ZorD in type I Zorya systems1,2.

Jan 3, 2024 | nature.com | Marek Basler |Petr Broz |Knut Drescher |Alexander Harms |Andreas Hierlemann |Sebastian Hiller | +11 more

In vitro models mimicking in-patient conditions have the potential to yield exciting opportunities for antibiotic research and revitalize future antibiotic discovery and development. Antibiotics have revolutionized modern medicine. However, their usefulness in treating bacterial infections and as prophylactics accompanying chemotherapy or surgery is under threat by the rise of antibiotic-resistant bacteria.