Pierre J. Rizkallah

Sep 17, 2024 | jci.org | Jesusa Capera |Michael L. Dustin |Garry Dolton |Pierre J. Rizkallah

AbstractMicrobial mimicry, the process in which a microbial antigen elicits an immune response and breaks tolerance to a structurally related self-antigen, has long been proposed as a mechanism in autoimmunity. In this issue of the JCI, Dolton et al. extend this paradigm by demonstrating that a naturally processed peptide from Klebsiella oxytoca acts as a superagonist for autoreactive T cells in type 1 diabetes (T1D).