Pilar Domingo-Calap

Nov 1, 2024 | biorxiv.org | Celia Ferriol-Gonzalez |Pilar Domingo-Calap

AbstractPhage-host interactions have been studied using one or a few phages and hosts in simple, controlled systems. Here, we implemented an experimental design to evolve a 12-phage cocktail in a highly diverse environment, including a combination of 39 Klebsiella spp. capsular types.

May 22, 2024 | nature.com | Dimitri Boeckaerts |Michiel Stock |Celia Ferriol-Gonzalez |Rafael Sanjuán |Pilar Domingo-Calap |Bernard De Baets

AbstractPhages are increasingly considered promising alternatives to target drug-resistant bacterial pathogens. However, their often-narrow host range can make it challenging to find matching phages against bacteria of interest. Current computational tools do not accurately predict interactions at the strain level in a way that is relevant and properly evaluated for practical use.