Rafael Sanjuán

May 22, 2024 | nature.com | Dimitri Boeckaerts |Michiel Stock |Celia Ferriol-Gonzalez |Rafael Sanjuán |Pilar Domingo-Calap |Bernard De Baets

AbstractPhages are increasingly considered promising alternatives to target drug-resistant bacterial pathogens. However, their often-narrow host range can make it challenging to find matching phages against bacteria of interest. Current computational tools do not accurately predict interactions at the strain level in a way that is relevant and properly evaluated for practical use.

Dec 20, 2023 | biorxiv.org | Jérémy Dufloo |Rafael Sanjuán

AbstractSARS-CoV-2 infects both the upper and lower respiratory tracts, which are characterized by different temperatures (33 degrees C and 37 degrees C, respectively). In addition, fever is a common COVID-19 symptom. SARS-CoV-2 has been shown to replicate more efficiently at low temperatures but the effect of temperature on different viral proteins remains poorly understood. Here, we investigate how temperature affects the SARS-CoV-2 spike function and evolution.