Rafael Sanjuán

May 22, 2024 | nature.com | Dimitri Boeckaerts |Michiel Stock |Celia Ferriol-Gonzalez |Rafael Sanjuán |Pilar Domingo-Calap |Bernard De Baets

AbstractPhages are increasingly considered promising alternatives to target drug-resistant bacterial pathogens. However, their often-narrow host range can make it challenging to find matching phages against bacteria of interest. Current computational tools do not accurately predict interactions at the strain level in a way that is relevant and properly evaluated for practical use.

Dec 20, 2023 | biorxiv.org | Jérémy Dufloo |Rafael Sanjuán

AbstractSARS-CoV-2 infects both the upper and lower respiratory tracts, which are characterized by different temperatures (33 degrees C and 37 degrees C, respectively). In addition, fever is a common COVID-19 symptom. SARS-CoV-2 has been shown to replicate more efficiently at low temperatures but the effect of temperature on different viral proteins remains poorly understood. Here, we investigate how temperature affects the SARS-CoV-2 spike function and evolution.

Feb 14, 2023 | nature.com | Timothée Bruel |Françoise Porrot |Piet Maes |Nathalie Morel |Jérémy Dufloo |Rafael Sanjuán | +2 more

AbstractConvergent evolution of SARS-CoV-2 Omicron BA.2, BA.4, and BA.5 lineages has led to the emergence of several new subvariants, including BA.2.75.2, BA.4.6. and BQ.1.1. The subvariant BQ.1.1 became predominant in many countries in December 2022. The subvariants carry an additional and often redundant set of mutations in the spike, likely responsible for increased transmissibility and immune evasion. Here, we established a viral amplification procedure to easily isolate Omicron strains.