Poppy Z. Grimes

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Genetic Architectures of Adolescent Depression Trajectories in 2 Longitudinal Population Cohorts

May 15, 2024 | jamanetwork.com | Mark Adams |Amelia J. Edmonson-Stait |Andrew McIntosh |Andrew Mcintosh |Poppy Z. Grimes

Key PointsQuestion Could multitrait polygenic risk scores be used to strengthen genetic prediction of longitudinal depression across adolescence? Findings In this longitudinal cohort replication study of 14 112 adolescents, stronger effect sizes of multitrait polygenic risk association with adverse depression trajectories were found compared with unitrait genetic risk.

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