Poul H Sorensen

Jan 18, 2024 | cell.com | Alberto Delaidelli |Poul H Sorensen

Hofman et al. reveal a novel survival mechanism in high-risk childhood medulloblastoma through the translation of non-canonical open reading frames (ORFs). The study uncovers the critical role of these often-overlooked ORFs, particularly the ASNSD1-uORF, in medulloblastoma cell survival, offering new avenues for targeted therapies in pediatric cancer.