Prathapan Thiru

Jun 13, 2024 | journals.plos.org | Jaclyn M Fingerhut |Romain Lannes |Troy W Whitfield |Prathapan Thiru

Loading metrics Open Access Peer-reviewedResearch Article ? This is an uncorrected proof. Citation: Fingerhut JM, Lannes R, Whitfield TW, Thiru P, Yamashita YM (2024) Co-transcriptional splicing facilitates transcription of gigantic genes. PLoS Genet 20(6): e1011241.

Apr 2, 2024 | biorxiv.org | Romain Lannes |Prathapan Thiru

AbstractAlthough introns are typically tens to thousands of nucleotides, there are notable exceptions. In flies as well as humans, a small number of genes contain introns that are more than 1000 times larger than typical introns, exceeding hundreds of kilobases (kb) to megabases (Mb). It remains unknown why gigantic introns exist and how cells overcome the challenges associated with their transcription and RNA processing.