Pu Chen

Nov 6, 2024 | nature.com | Linliang Zhang |Chao Shan |Pu Chen |Rui Huang |Yu Chen

AbstractFlaviviruses strategically utilize the endoplasmic reticulum (ER) in their replication cycles. However, the role of ER autophagy (ER-phagy) in viral replication process remains poorly understood. Here, we reveal that prolonged Zika virus (ZIKV) infection results from the degradation of ER-phagy receptor FAM134B, facilitated by viral NS2A protein. Mechanistically, ER-localized NS2A undergoes K48-linked polyubiquitination at lysine (K) 56 by E3 ligase AMFR.

May 2, 2024 | onlinelibrary.wiley.com | Sajid Umar |Shaban Muhammad |Di Gao |Pu Chen

Dear Editor, The interconnections between humans, animals, and the environment are often referred to as the “One Health” concept. These connections are complex and closely intertwined. During the last two decades, cat population has expanded rapidly worldwide including China. There are approximately 65 million cats in China, indicating that cats have become one of the most popular pets.

Oct 4, 2023 | onlinelibrary.wiley.com | Qiang Yao |Pu Chen |Xiaoying Fu

LETTER TO THE EDITOR Rare myeloperoxidase-negative rectangular inclusions in acute promyelocytic leukemia after induction therapy Qiang Yao, Qiang Yao Department of Laboratory Medicine, Shenzhen Children's Hospital, Shenzhen, Guangdong, China Search for more papers by this authorPu Chen, Pu Chen Department of Laboratory Medicine, Zhongshan Hospital Fudan University, Shanghai, China Search for more papers by this authorXiaoying Fu, Corresponding Author Xiaoying Fu Department of Laboratory...

Aug 2, 2023 | nature.com | Runhao Zhang |Pu Chen |Zhen Gu |Libo Jiang

AbstractChemotherapy remains as the first-choice treatment option for triple-negative breast cancer (TNBC). However, the limited tumor penetration and low cellular internalization efficiency of current nanocarrier-based systems impede the access of anticancer drugs to TNBC with dense stroma and thereby greatly restricts clinical therapeutic efficacy, especially for TNBC bone metastasis.