Purvi Saxena

Mar 31, 2023 | dx.doi.org | Harsh V Thakkar |Sayan Chatterjee |Rameswari Eerla |Purvi Saxena

α-Synuclein (α-Syn) misfolding and its presence in Lewy bodies are observed in almost all Parkinson’s disease (PD) patients. Basic biomedical research would benefit from a quick, low-cost approach to purifying α-Syn and developing in vitro and in vivo models for PD. Several research groups utilize PFF-based models, yet the production of α-Syn PFFs is inconsistent, resulting in nonconclusive findings.