Qianqian Huang

Jan 14, 2025 | mdpi.com | Ying Chen |Hao Wu |Qianqian Huang |Jingwen Liao

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Nov 27, 2023 | onlinelibrary.wiley.com | Peng Yang |Qianqian Huang |Jianhua Zhang |Yiwen Li

The abnormal amyloid-β accumulation is essential and obbligato in Alzheimer's disease pathogenesis and natural polyphenols exhibited great potential as amyloid aggregation inhibitors. However, the poor metabolic stability, low bioavailability, and weak blood-brain barrier crossing ability of natural polyphenol molecules fail to meet clinical needs. Here, we develop a universal protocol to prepare natural polyphenolic nanodots by heating in aqueous solution without unacceptable additives.