Qianyi Pu

Jul 12, 2024 | biorxiv.org | Erin Ritchie |Siming Zhong |Yunbo Li |Qianyi Pu

AbstractThe conserved MAP3K12/Dual Leucine Zipper Kinase (DLK) plays versatile roles in neuronal development, axon injury and stress responses, and neurodegeneration, depending on cell-type and cellular contexts. Emerging evidence implicates abnormal DLK signaling in several neurodegenerative diseases. However, our understanding of the DLK-dependent gene network in the central nervous system remains limited.