Qin Ni

Nov 22, 2024 | cell.com | Qin Ni |Zhuoxu Ge |Yizeng Li |Gabriel Shatkin |Jinyu Fu |Anindya Sen | +9 more

Keywordscell volumenucleus volumemechanosensationNHE1cytoskeletonPI3KERK/MAPKepigenomeRNA-seqmath modelResearch topic(s)CP: Cell biologyIntroductionCells actively control their size during the cell cycle, and failure of cell size control is an indicator of disease.1,2,3,4,5 Cell size or volume influences all intracellular biochemical reactions by affecting concentrations of cytoplasmic components.

Apr 18, 2024 | biorxiv.org | Qin Ni |Zhuoxu Ge |Yizeng Li |Gabriel Shatkin

AbstractMammalian cells can rapidly respond to osmotic and hydrostatic pressure imbalances during an environmental change, generating large fluxes of water and ions that alter cell volume within minutes. While the role of ion pump and leak in cell volume regulation has been well-established, the potential contribution of the actomyosin cytoskeleton and its interplay with ion transporters is unclear.

Sep 3, 2023 | biorxiv.org | Qin Ni |Zhuoxu Ge |Yizeng Li |Gabriel Shatkin

AbstractThe regulation of mammalian cell volume is crucial for maintaining key cellular processes. Cells can rapidly respond to osmotic and hydrostatic pressure imbalances during environmental challenges, generating fluxes of water and ions that alter volume within minutes. While the role of ion pump and leak in cell volume regulation has been well-established, the role of the actomyosin cytoskeleton and its substantial interplay with ion transporters are still unclear.