Yizeng Li

Nov 22, 2024 | cell.com | Qin Ni |Zhuoxu Ge |Yizeng Li |Gabriel Shatkin |Jinyu Fu |Anindya Sen | +9 more

Keywordscell volumenucleus volumemechanosensationNHE1cytoskeletonPI3KERK/MAPKepigenomeRNA-seqmath modelResearch topic(s)CP: Cell biologyIntroductionCells actively control their size during the cell cycle, and failure of cell size control is an indicator of disease.1,2,3,4,5 Cell size or volume influences all intracellular biochemical reactions by affecting concentrations of cytoplasmic components.

May 13, 2024 | link.aps.org | Yizeng Li |Sean Sun |Johns Hopkins

Anisotropic environmental signals or polarized membrane ion/solute carriers can generate spatially varying intracellular gradients, leading to polarized cell dynamics. For example, the directional migration of neutrophils, galvanotaxis of glioblastoma, and water flux in kidney cells all result from the polarized distribution of membrane ion carriers and other intracellular components.

Apr 18, 2024 | biorxiv.org | Qin Ni |Zhuoxu Ge |Yizeng Li |Gabriel Shatkin

AbstractMammalian cells can rapidly respond to osmotic and hydrostatic pressure imbalances during an environmental change, generating large fluxes of water and ions that alter cell volume within minutes. While the role of ion pump and leak in cell volume regulation has been well-established, the potential contribution of the actomyosin cytoskeleton and its interplay with ion transporters is unclear.

Jan 20, 2024 | ca.news.yahoo.com | Yizeng Li

Cell migration, or how cells move in the body, is essential to both normal body function and disease progression. Cell movement is what allows body parts to grow in the right place during early development, wounds to heal and tumors to become metastatic. Over the last century, how researchers understood cell migration was limited to the effects of biochemical signals, or chemotaxis, that direct a cell to move from one place to another.

Jan 20, 2024 | nz.news.yahoo.com | Yizeng Li

Cell migration, or how cells move in the body, is essential to both normal body function and disease progression. Cell movement is what allows body parts to grow in the right place during early development, wounds to heal and tumors to become metastatic. Over the last century, how researchers understood cell migration was limited to the effects of biochemical signals, or chemotaxis, that direct a cell to move from one place to another.