Qingbo Wang

Sep 27, 2024 | nature.com | Qingbo Wang |Ho Namkoong |Ryunosuke Saiki |Kyuto Sonehara |Shuhei Azekawa |Yugo Takahashi | +12 more

Correction to: Nature Genetics https://doi.org/10.1038/s41588-024-01896-3, published online 24 September 2024. In the version of the article initially published, there was an error in the x-axis label of Fig. 1a, where in the text now reading “pQTL –log10(P) ≥ x” it originally read “… ≤ x.” In the keys to both graphs in Fig. 7b, the blue dot was listed as “β > 0” and has now been amended to “β < 0.” The symbols are corrected in the HTML and PDF versions of the article.

Sep 24, 2024 | nature.com | Qingbo Wang |Ho Namkoong |Ryunosuke Saiki |Kyuto Sonehara |Shuhei Azekawa |Saori Sakaue | +12 more

AbstractStudying the genetic regulation of protein expression (through protein quantitative trait loci (pQTLs)) offers a deeper understanding of regulatory variants uncharacterized by mRNA expression regulation (expression QTLs (eQTLs)) studies. Here we report cis-eQTL and cis-pQTL statistical fine-mapping from 1,405 genotyped samples with blood mRNA and 2,932 plasma samples of protein expression, as part of the Japan COVID-19 Task Force (JCTF).

Jan 15, 2024 | nature.com | Masahiro Kanai |Qingbo Wang |Jessica Alföldi |William Phu |Yossi Farjoun |Anne H. O’Donnell-Luria | +4 more

Correction to: Nature https://doi.org/10.1038/s41586-023-06045-0 Published online 6 December 2023In the version of this article initially published, data points did not appear in Supplementary Figs. 6–8, and are now included in the online version of the Supplementary Information. About this articleChen, S., Francioli, L.C., Goodrich, J.K. et al. Author Correction: A genomic mutational constraint map using variation in 76,156 human genomes. Nature (2024).

Dec 6, 2023 | nature.com | Masahiro Kanai |Qingbo Wang |Jessica Alföldi |Yossi Farjoun |Anne H. O’Donnell-Luria |Alicia Martin | +4 more

AbstractThe depletion of disruptive variation caused by purifying natural selection (constraint) has been widely used to investigate protein-coding genes underlying human disorders1,2,3,4, but attempts to assess constraint for non-protein-coding regions have proved more difficult.

Nov 2, 2023 | mdpi.com | Qingbo Wang |Jianyong Hu |Mingming Song |Hui Shen

2. Physical Tests of Gas–Liquid Two-Phase Pipe Flow 2.1. Test PlatformFigure 2 shows the system layout of the water–air flow test platform. The test system is mainly composed of a water supply system, a gas supply system and a data acquisition system. The water supply module mainly consisted of a low-level water tank, a horizontal centrifugal pump, pressurized pipelines and an electric control valve.