Qinghua Zhou

Aug 21, 2024 | nature.com | Wenjun Wang |Qinghua Zhou

replying to M. Llovera et al. Nature Communications https://doi.org/10.1038/s41467-024-51447-x (2024)The authors welcome the opportunity to address Llovera and colleagues’ questions and concerns about our article. About the concern that ENDOG-regulated lipid metabolism requires its translocation from mitochondria, Llovera et al.

May 23, 2024 | nature.com | Hao Liu |Qinghua Zhou

AbstractWhen cells are stressed, DNA from energy-producing mitochondria can leak out and drive inflammatory immune responses if not cleared. Cells employ a quality control system called autophagy to specifically degrade damaged components. We discovered that mitochondrial transcription factor A (TFAM)—a protein that binds mitochondrial DNA (mtDNA)—helps to eliminate leaked mtDNA by interacting with the autophagy protein LC3 through an autolysosomal pathway (we term this nucleoid-phagy).

Oct 2, 2023 | nature.com | Liang Chen |Qinghua Zhou |Hongjie Zhang

AbstractPIWI-interacting RNAs (piRNAs) are small noncoding RNAs that regulate gene expression, yet their molecular functions in neurobiology are unclear.