R. Eric Davis

Feb 1, 2024 | science.org | Zi-Xian Liu |Skye Montoya |Shou Qiu |R. Eric Davis

PerspectiveMedicineRedirecting targeted proteins for degradation can overcome acquired drug resistanceR. Eric Davis [email protected] and Jason R. WestinAuthors Info & AffiliationsAbstractAmino acid sequence determines a protein’s behavior, including drug susceptibility and its interacting proteins. Genomic instability enables cancer development but can also produce variants of proteins that resist targeted therapy, sometimes by changing the protein’s function and protein partners.