Rajula Elango

Dec 3, 2024 | cell.com | Rajula Elango |Namrata Nilavar |Andrew Li |Daniel Nguyen |Emilie Rass |Erin E. Duffey | +5 more

Apr 10, 2024 | biorxiv.org | Rajula Elango |Andrew Li |Erin E. Duffey |Namrata Nilavar

AbstractCollision of a replication fork with a DNA nick is thought to generate a one-ended break, fostering genomic instability. Collision of the opposing converging fork with the nick could, in principle, form a second DNA end, enabling conservative repair by homologous recombination (HR). To study mechanisms of nickase-induced HR, we developed the Flp recombinase step arrest nickase in mammalian cells.