Ran Yang

Nov 27, 2024 | nature.com | Ran Yang

AbstractLoading of replicative helicases is obligatory for the assembly of DNA replication machineries. The eukaryotic MCM2–7 replicative helicase motor is deposited onto DNA by the origin recognition complex (ORC) and co-loader proteins as a head-to-head double hexamer to license replication origins. Although extensively studied in budding yeast1,2,3,4, the mechanisms of origin licensing in multicellular eukaryotes remain poorly defined.

Nov 13, 2024 | chemistry-europe.onlinelibrary.wiley.com | Qin Li |Ran Yang |Sirui Liu |Zhanzhen Ma

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Dec 6, 2023 | nature.com | Mariam Okhovat |Rory Sheng |Yafei Mao |Ana C. Lima |Alexandra Stendahl |Ran Yang | +5 more

AbstractTopological associating domains (TADs) are self-interacting genomic units crucial for shaping gene regulation patterns. Despite their importance, the extent of their evolutionary conservation and its functional implications remain largely unknown.