Rory Sheng

Mar 8, 2024 | cell.com | Rory Sheng |Elizabeth Murray

Highlights•A scoliosis-associated region, PEC7, is an enhancer in the mouse tail and intervertebral disc•Deletion of Xe1 or both Xe1 and PEC7 enhancers leads to a kinky tail phenotype•Deletion of Xe1 and PEC7 together leads to a female-biased kinky tail•Tamoxifen suppresses the sex dimorphic phenotype, suggesting a role for estrogen signalingSummaryAdolescent idiopathic scoliosis (AIS), a sideways curvature of the spine, is sexually dimorphic, with increased incidence in females.

Dec 6, 2023 | nature.com | Mariam Okhovat |Rory Sheng |Yafei Mao |Ana C. Lima |Alexandra Stendahl |Ran Yang | +5 more

AbstractTopological associating domains (TADs) are self-interacting genomic units crucial for shaping gene regulation patterns. Despite their importance, the extent of their evolutionary conservation and its functional implications remain largely unknown.