Ras Baizureen Roseli

Jan 12, 2024 | pubs.rsc.org | Yuchen Zhou |Molecular Biosciences |Ras Baizureen Roseli |Natasha L. Hungerford

Binding of the plant-derived toxin simplexin to bovine protein kinase C: insights from molecular dynamics† Pimelea poisoning of cattle is toxicologically linked to the activation of bovine protein kinase C (PKC) by the plant-derived toxin simplexin. To understand the affinity of PKC for simplexin, we performed molecular dynamics (MD) studies of simplexin, simplexin analogues, and several other activators of PKC.